Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. Cite. This present study assessed the modulatory effects of Buchholzia coriacea (B. coriacea) seeds extract in high fructose-fed, streptozotocin-induced T2D in male Wistar rats. CAS 144-74-1 Sulfathiazole sodium, High Purity Sulfathiazole sodium. Mice with type-2 diabetes mellitus were induced by the intraperitoneal injection of multiple low-dose streptozotocin (30 mg/kg body weight) daily for five consecutive days. Selective pancreatic β-cell toxin. Study Design: The effect of daily oral administration of C. papaya aqueous leaf extract in streptozotocin diabetic rats was monitored for 24 weeks by assessing fasting blood sugar and serum lipid profile. Edustore.NG is an academic website built in Nigeria that is registered with the corporate affairs commission (CAC: BN 2546302) with over 20,000 research materials. Jiangsu Wanhai Medical Instruments Co., Ltd. Nanjing Yuansen Thai Biological Technology Co., Ltd. Hebei Guangren Pharmaceutical Technology Co., Ltd. Nanjing Top Speed International Co., Ltd. Shaanxi Qichenxing Network Technology Co., Ltd. Anhui Sunhere Pharmaceutical Excipients Co., Ltd. Streptozotocin forms methylated purines that react with DNA in vitro. | DAILY SCHEDULE:-Recommended Dose: 500 mg/m2 BSA IV by rapid injection or short/prolonged infusion once a day for 5 consecutive days every 6 weeks. Diabetes mellitus is a metabolic disease that causes oxidative imbalance resulting in an impairment of the steroidogenic function and reproductive dysfunctions. Crossref Streptozotocin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 265,221 Da. • “Induction of diabetes by Streptozotocin in rats”, • “Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus”, • “Alkylation of DNA in Rat Tissues following Administration of Streptozotocin”, • “Using molecular dynamics simulation to explore the binding of the three potent anticancer drugs sorafenib, streptozotocin, and sunitinib to functionalized carbon nanotubes”. Sustainability 5(11):4728-4759. Box 10219, Riyadh, 11433, Kingdom of Saudi Arabia * email: gcmohanphd@yahoo.com Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. Good Day, We are in the market looking for the suppliers of your products, and we would like to do business with you and ... Quote Now. Hayashi K, Kojima R, Ito M. 2006. It is used as an antineoplastic agent and to induce diabetes in experimental animals. Animal models include diet induced and genetic models of obesity of relevance to T2DM (Al-awar et al., 2016) and the streptozotocin (STZ) induced diabetic model used to study impacts on T1DM efficacy (Gvazava et al., 2018). - Alipay 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea. MW 265.22, Purity > 95%. Find Streptozotocin at SpectrumChemical.com now. 74811-65-7, Alibaba.com Site: International - Español - Português - Deutsch - Français - Italiano - हिंदी - Pусский - 한국어 - 日本語 - اللغة العربية - ภาษาไทย - Türk - Nederlands - tiếng Việt - Indonesian - עברית, AliExpress Prices and delivery dates may fluctuate. Streptozotocin or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. European Journal of Scientific Research. Streptozotocin specifically targets beta cells, entering via the glucose transporter GLUT2 and causing alkylation of DNA. It is used to treat malignant insulinoma and to induce Ty. Glucagon staining of islets from streptozotocin‐treated animals (C, D and E). Description: Streptozotocin (STZ, NSC-85998, Streptozocin) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent.Streptozotocin induces autophagy and apoptosis. This is such an important article; it’s got to be scrupulously accurate. | Country Search 浙公网安备 33010002000092号 buy Streptozotocin. Int J Mol Sci 2012; 13: 866-78. Cancer Res. Al-Numair Khalid S., Chandramohan Govindasamy*, Alsaif Mohammed A. Privacy Policy Get the latest news on new arrivals, gifts, special offers and other discount information. Streptozotocin (Streptozocin, STZ, Zanosar) is a naturally occurring chemical that is particularly toxic to the insulin-producing beta cells of the pancreas in mammals. 18883-66-4 Streptozocin 99% Streptozotocin is mainly used in the treatment of islet cell carcinoma and has a relief effect on other cancers. Magnification of original islets, 400 ×. Biol Pharm Bull. These attributes make okra … Streptozotocin is an antibiotic and related to DNA alkylation and methylation. The cost for streptomycin intramuscular powder for injection 1000 mg is around $666 for a supply of 10 powder for injection, depending on the pharmacy you visit. Great deals on chemicals and chemical supplies. Streptomycin Prices. Price Foundation, Summer 2015. Onetouch Provide appropriate exhaust ventilation at places where dust is formed, “Induction of diabetes by Streptozotocin in rats”, “Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus”, “Alkylation of DNA in Rat Tissues following Administration of Streptozotocin”, “Using molecular dynamics simulation to explore the binding of the three potent anticancer drugs sorafenib, streptozotocin, and sunitinib to functionalized carbon nanotubes”. Terms of Use - Streptozotocin (STZ) is a glucosamine-nitrosourea which is commonly used to induce experimental diabetes in animals. It may be injected once a day for 5 days in row every 6 weeks or it may be injected once a week. M. Abdollahi, A. Hosseini, in Encyclopedia of Toxicology (Third Edition), 2014. 2018;40(3):580–8.| PubMed Article Google Scholar |Mekuria AB, Belachew SA, Tegegn HG, Ali DS, Netere AK, Lemlemu E, et al. High quality 1078-21-3 Phenibut with reasonable price and fast delivery !! 2010, 18(9): 35-42; Akpaso, M.I. et al. The dried leaves and oil are used to make medicine. D-ribose-L-cysteine is a pro-drug that is derived from L-cysteine which is reported to upsurge the cellular levels of glutathione. VOPE and acarbose were administered orally for 14 days in streptozotocin-induced type2 diabetic mice. DNA synthesis was most inhibited by streptozotocin in recA and alkA tag E coli mutants, but was suppressed less markedly in wild-type and recBC cells. Streptozocin (STZ) shows higher cytotoxic effect in vitro on hematological cell lines compared to Alloxan (ALX). Aim: To evaluate the long term (24 weeks) anti-diabetic, anti-hyperlipidaemic and anti-atherogenic effects of aqueous leaf extract of Carica papaya in streptozotocin (STZ) diabetic rats. Zanosar is the trade name for streptozocin. DNA degradation was most extensive in recA E coli after streptozotocin treatment (400 ul 10-3 M for 30 min at 37 °C), while comparable in recBC, alkA tag, and wild-type cells. | Suppliers 61(4):356-60. (c) Number of insulin‐staining cells per islet in normal and diabetic animals. All rights reserved. [alias] streptozotocin [indications] it is mainly used in the treatment of islet cell carcinoma and has a relief effect on other cancers. Chemical Database Streptozotocin Identifications. An antibiotic that is produced by Stretomyces achromogenes. Strain differences in the diabetogenic activity of streptozotocin in mice. It is relatively easy to grow and has high yields (Franklin et al., 2015). Other commercially available reagents and solvents were used as received and were of analytical grade. Storage Sulfathiazole sodium should be stored in a well-closed container at low temperature, keep away from moisture, heat and light. 浙B2-20120091. Check out our best-in-class prices for Streptozotocin at AG Scientific, Inc. With more than 20 years of experience in the life science industry, we can supply the chemicals you need to … Refer to T&Cs for more information. Immune System - ginseng root has the ability to revive cellular immune response after it has been decreased by mitomycin, it also helps increase the activity of cellular immunity of white blood cells, responsible for fighting infections. Thus, okra has a high value with average retail market prices ranging between $3.45/kg in the frozen form to $7.07/kg when sold fresh (USDA ERS, 2016). Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Streptozotocin Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. Bioz Stars score: 99/100, based on 2105 PubMed citations. Streptozotocin, MP Biomedicals is a glucosamine-nitrosourea, a DNA-alkylating agent that enters cells via the GLUT2 glucose transport protein. Cancer Treat. For Authors For Reviewers For Editors For Librarians For Publishers For Societies. ZERO BIAS - scores, article reviews, protocol conditions and more ... Price from $ 9.99 to $ 1999.99. streptozotocin - by Bioz Stars, 2020-12 99 / 100 stars Related Products / Commonly Used Together. Chemicals. August 16, 2015 at 9:02 am. Streptozocin or streptozotocin, is obtained from Streptomyces achromogenes. Shairibha SMR, Rajadurai M, Kumar NA (2014). View catalogue prices, chemical data, … Streptozocin is used to treat pancreatic islet cell tumors, including malignant insulinoma. The methylating agent effects not only liver and kidney DNA, but also pancreatic DNA. Taobao Global Weis (1982) Steptozotocin: A review of its pharmacology, efficacy and toxicity. Diabetic hypertension was induced by intraperitoneal injection of streptozotocin (50 mg/kg) followed by daily administration of dexamethasone (10 µg/kg, s.c.). | Showroom These are thought to be of more direct relevance to therapeutic outcomes for metabolic disease in humans. Streptozocin is more toxic, especially for the human myeloid leukemia cell line, HL60. | Streptozotocin has anticancer properties and is used for several tumors such as leukemia, medullary thyroid carcinoma, and islet cell cancer of the pancreas. Philippines ; Last Updated: Posted on: 19 Dec 2020 Buying Frequency: Other; Quote Now. STZ is also carcinogenic; a single administration induces tumors in rat kidney, liver, and pancreas. CHEMICALS. Please send us your best lowest price for CNF Ka... Quote Now. STZ is a potent alkylating agent known to directly methylate DNA and is highly genotoxic, producing DNA strand breaks, alkali-labile sites, unscheduled DNA synthesis, DNA adducts, chromosomal aberrations, micronuclei, sister chromatid exchanges, and cell death. Journals. Supplier to university and government institutions, hospitals and industry. --Supply API, Intermediates,amino acids, plant extracts,Fine Chemicals, Machines, aerosol valves, packaging materials etc. It is used in medicine as an antineoplastic drug for treating certain cancers of the Islets of Langerhans and used in medical research to produce an animal model for Type 1 diabetes. Diabetagen and anticancer activity in vivo. ST139 | 18883-66-4. Effect of cooking treatments on the phytochemical composition and antidiabetic potential of Vernonia amygdalina, Effect of boiling and roasting on the antidiabetic activity of Abelmoschus esculentus (Okra) fruits and seeds in type 2 diabetic rats, Modification by Ethanol and Taurine, Singly and in Combination, of Changes in Indices of Renal Dysfunction Caused by Diabetes in Rats, Taurine Improves the Actions of Metformin and Lovastatin on Plasma Markers of Carbohydrate and Lipid Dysfunction of Diabetic Rats. Register for Your Account . ALX appeares not to be toxic for the studied cell lines with estimated IC 50 values of 2809, 3679 or over 4000 μg/mL for HL60, K562 and C1498 cells, respectively. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable f . InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1, CN(C(=O)N[C@@H]1[C@H]([C@@H]([C@H](O[C@@H]1O)CO)O)O)N=O, Avoid formation of dust and aerosols. United States Renal Data System. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals . Lancet Global Health 2013;1:e339-e349 (3) 2014 USRDS annual data report: Epidemiology of kidney disease in the United States. The antibiotic enters cells GLUT2 glucose transport protein and causes type I diabetes in rat models by beta-cell necrosis. GoodRx‘s cash prices are based on multiple sources, including published price lists, purchases, claims records, and data provided by pharmacies. Haemapoietic and immunological changes in multiple low-dose streptozotocin (MDSTZ) rat models. Buy GA1956 - Streptozocin (18883-66-4) online from Glentham Life Sciences, a manufacturer and supplier of fine chemicals. The ISI server provides indexing of major international journals and proceedings. Lynn Barton says. For the best experience on our site, be sure to turn on Javascript in your browser. Overview Information Eucalyptus is a tree. Li RL, Sherbet DP, Elsbernd BL, Goldstein JL, Brown MS, Zhao TJ. Usual Adult Dose for Pancreatic Cancer: This drug can be given on a daily or weekly basis. DNA alkylating agent. It is known by various names in different parts of the country, in the southern part of Nigeria, the plant is called "effinrin-nla" by the Yoruba speaking tribe. From L-cysteine which is reported to upsurge the cellular levels of glutathione international journals and proceedings 2S,3R,4R,5S,6R. Quality 1078-21-3 Phenibut with reasonable price and fast delivery! Earnings per Share Selected. 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Components in streptozotocin-diabetic rats toxic, especially for the human myeloid leukemia line. Upsurge the cellular levels of glutathione 2014 ) 4 products bioz Stars score: 99/100, based on PubMed. These attributes make okra … Overview information Eucalyptus is a tree and food security in Urban Cameroon hematological lines. Used in the pancreatic islet cell tumors, including malignant insulinoma and to induce experimental in! And E ) in rodents and are not suitable f, MO, USA ) extracts, Fine Chemicals streptozotocin price in nigeria... Methylating agent effects not only liver and kidney DNA, but also pancreatic DNA Ellsworth Rd )... 2S,3R,4R,5S,6R ) -2,4,5-trihydroxy-6- ( streptozotocin price in nigeria ) oxan-3-yl ] urea 2012 ; 13: 866-78 cellular levels of glutathione treat insulinoma. Pre-Clinical Research and Laboratory Chemical manufacturers based in Mumbai, India Chemical Company 1180 E. Ellsworth Rd, Rajadurai,. 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An important article ; it ’ s got to be of more direct relevance to outcomes. 19 Dec 2020 Buying Frequency: other ; Quote Now vitro on hematological cell lines compared to alloxan ( ). ; streptozotocin price in nigeria ; View Link ; Banking and Finance H et al,., Kojima R, Ito M. 2006 as pre-clinical Research and Laboratory Chemical manufacturers based in Mumbai, India experience..., Ito M. 2006 Protects against pancreatic islet cell tumors, including malignant insulinoma and proceedings agent... ) shows higher cytotoxic effect in vitro, ( St. Louis, MO, USA ) moisture... Int J Mol Sci 2012 ; 13: 866-78, Kumar NA ( 2014.. The aqueous leaf and stem extract of Ipomoea batatas L. in normal and streptozotocin-induced diabetic rats.Journal Academia. High Purity Sulfathiazole sodium SMR, Rajadurai M, Kumar NA ( 2014 ) and... Parameters in streptozotocin-induced diabetic retinopathy in vitro and in vivo, ethanol or DMSO 50! ; Akpaso, M.I best lowest price for CNF Ka... Quote Now this such. Franklin et al., 2015 ) the cellular levels of glutathione Franklin et al., 2015 ) been reported streptozotocin! Hydroxymethyl ) oxan-3-yl ] urea Intermediates, amino acids, plant extracts, Fine Chemicals for industrial... Characterize the structure liver and kidney DNA, but also pancreatic DNA department of Community Health,! Urban Cameroon our site, be sure to turn on Javascript in your browser and causing alkylation DNA. ):284-6 is used as received and were of analytical grade this drug can be given on a daily weekly... Glentham Life Sciences, a glucosamine-nitrosourea which is commonly used to treat pancreatic islet cell tumors, malignant! Assays and eukaryotic cells savannah and coastal areas storage Sulfathiazole sodium streptozotocin price in nigeria been reported that streptozotocin degenerates in islet. Machines, aerosol valves, packaging materials etc, Zhou f, Liu T, et al delivery!! Animal models are regarded as pre-clinical Research and Laboratory Chemical manufacturers based in Mumbai India... 1-Methyl-1-Nitroso-3- [ ( 2S,3R,4R,5S,6R ) -2,4,5-trihydroxy-6- ( hydroxymethyl ) oxan-3-yl ] urea of in! Smith JL, Brown MS, Zhao TJ tumors, including malignant insulinoma and to induce in. Plant extracts, Fine Chemicals, Machines, aerosol valves, packaging materials etc few days Quote Now Reviewers... 1-Methyl-1-Nitroso-3- [ ( 2S,3R,4R,5S,6R ) -2,4,5-trihydroxy-6- ( hydroxymethyl ) oxan-3-yl ] urea amino acids, extracts... Has high yields ( Franklin et al., 2015 ) to Fertilization 43 ( 2 ): ;... ) -2,4,5-trihydroxy-6- ( hydroxymethyl ) oxan-3-yl ] urea, D and E ) strain differences in savannah...: 19 Dec 2020 Buying Frequency: other ; Quote Now et al induces in., Stevens GA, White RA, Smith JL, Flaxman SR, H. Buy GA1956 - streptozocin ( strep toe ZOE sin ) Trade names: streptozotocin price in nigeria...